However, the effects of minoxidil are transient and may cause contact dermatitis or hypertrichosis, and finasteride usage is contraindicated in women 5
Sources: Seiwerth S;Rucman R;Turkovic B;Sever M;Klicek R;Radic B;Drmic D;Stupnisek M;Misic M;Vuletic LB;Pavlov KH;Barisic I;Kokot A;Japjec M;Blagaic AB;Tvrdeic A;Rokotov DS;Vrcic H;Staresinic M;Sebecic B;Sikiric P
The copper coordination chemistry of GHK-Cu enables controlled cellular copper delivery while preventing the formation of reactive oxygen species characteristic of free copper toxicity, with the peptide's binding affinity (log K = 16.1) positioning it perfectly within the physiological copper transport hierarchy to facilitate controlled metal transfer to enzymatic targets including lysyl oxidase (essential for collagen cross-linking) and superoxide dismutase (critical for antioxidant defense)
Copper peptides exhibit a biphasic response, as researchers call it
Pauli WM, Larsen T, Collette S, Tyszka JM, Seymour B, O'Doherty JP
