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Slowly titrating the dose over months allows the body to clear the toxic burden without triggering a massive immune flare or severe Herxheimer reaction

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For example, while Gln and the Gln-Glu cycle are believed to regulate Glu, an increased cycle turnover could mitigate excessive glutamatergic activity and maintain a balanced excitatory tone [15, 61]

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Fourth, apply in vivo models to explore the therapeutic effect of microbiota-targeting treatments (such as metabolite supplements and microbial engineering) to restore iron homeostasis and ameliorate the OA progression and put forward evidence for clinical trials