(PubMed) Patel KP, O'Brien TW, Subramony SH, Shuster J, Stacpoole PW
This inhibitory effect occurs regardless of intra- or extracellular LCAC delivery, is completely reversible following wash-out, and is consistent across species and preparations (Wu and Corr, 1992
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The enzyme activity of thiopurine methyltransferase (TPMT) is determined genetically: 1 in 300 patients (0.3%) have no enzyme activity and have a very high risk of serious toxicity, such that these drugs should not be used