Timing: why fasted, and why evening GH secretagogues and GHRH analogs are studied on an empty stomach for a specific reason: dietary fat and the insulin/glucose rise that follows a meal blunt the GH pulse
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Both are studied for their effects on mood, anxiety, and cognition
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Some research from Germany has shown that an even higher threshold (over 500 pg/mL) is necessary in early-to-mid pregnancy to maintain vitamin B12 levels throughout pregnancy, lactation, and to support an infants vitamin B12 status (via breast milk) through 6 months of age
