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Comparing expectations across options Prescription medicines such as tirzepatide (injectable) and semaglutide (injectable) have produced much larger average weight loss in human clinical trials

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This circumstance is likely to be favored in the brain parenchyma given its high metabolic rate and elevated oxygen consumption, which inevitably will produce significant amounts of reactive oxygen species as by-products, including the highly reactive superoxide anion O 2 that is converted to H 2 O 2 (Drge, 2 O 2 produce iron(III) and generate the highly reactive hydroxyl radical OH at the expense of endogenous reducing agents, i.e., polyunsaturated fatty acids like DHA or arachidonic acid, generating lipoperoxyl radicals