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Watkins PB, Kaplowitz N, Slattery JT

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[5] The researchers also note that IR and IGF1R act as identical portals to the regulation of gene expression, with differences between insulin and IGF-1 effects due to a modulation of the amplitude of the signal created by the specific ligand-receptor interaction. The IGF-1R is referred to as the physiologic receptor due to its potential higher affinity (approximately 100 times higher) for IGF-1 as compared to the insulin receptor

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Cagrilintide has a larger molecule (37 aa, MW 3,924 Da) and dissolves more slowly