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The FEE-treated groups showed reduced MDA levels, correlating with histopathological improvements such as decreased synovial hyperplasia, lower inflammatory cell infiltration, and better cartilage integrity

The Biochemical Advantage The power of this combination lies in addressing multiple limiting factors in NO production simultaneously: L-citrulline elevates plasma arginine in a way that direct arginine supplementation cannot, creating a sustained supply of NO precursors

Proc Natl Acad Sci USA 101:72817286

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