Traditional practices have incorporated BV for its anti-inflammatory effects, pain relief properties, and immune system stimulation
SARS-CoV-2 is associated with changes in brain structure in UK Biobank
For RCTs, this included assessment of: (1) risk of bias (via Cochrane RoB 2 tool), (2) inconsistency of results across studies, (3) indirectness of evidence, (4) imprecision due to sample size or confidence intervals, and (5) potential publication bias
Timing of administration relative to surgical procedures, optimal dosing in perioperative settings, and integration with standard post-operative care protocols require clinical investigation before establishing evidence-based perioperative protocols
Some experimentation helps find your optimal schedule