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For example, IL-2 treatment has been shown to increase Treg numbers and reduce inflammation in COPD models (123)

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The PREMIER study: a multicenter, randomized, double-blind clinical trial of combination therapy with adalimumab plus methotrexate versus methotrexate alone or adalimumab alone in patients with early, aggressive rheumatoid arthritis who had not had previous methotrexate treatment

Non-response might indicate product quality issues, dosing inadequacy, injury severity beyond peptide help, or individual variation in response