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A high activity was encountered, Ki = 5.1 nM, to be compared with 23 (HA08) with a Ki of 3.3 nM, the latter comprising a 13-membered macrocyclic system

Poly(lactide- co -glycolide) (PLGA) PLGA is an FDA-approved biodegradable polymer extensively utilized in drug delivery systems due to its ability to encapsulate both hydrophobic and hydrophilic therapeutics

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