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Rheumatoid arthritis, lupus, and multiple sclerosis are widespread autoimmune diseases characterised by chronic inflammation and an overactive immune response

For instance, in an in vitro study, the pro-inflammatory cytokine IL-6 was suggested to be a key factor released by activated microglia, which in turn reduced neuronal differentiation and induced cell death in existing neurons [100]

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Specifically, PLB downregulated cytochrome C and ferritin, while upregulating TFAM and GPX4