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Polymorphisms of genes related to phase-I metabolic enzymes affecting the clinical efficacy and safety of clopidogrel treatment

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4.1.3 Inhibition of melanin synthesis by mediating MITF-related pathway It regulates the transcription of tyrosinase, tyrosinase-related protein 1 (TRP-1), and tyrosinase-related protein 2 (TRP-2), activates various target genes related to melanin synthesis, and influences the reproduction, proliferation, and survival of melanogenic cells (Wellbrock and Marais, 2005

Declaration of Interest SJ has no conflicts of interest to declare