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The upregulation and activation of 7nAChR subsequently activate several signaling pathways, including neuroprotective PI3K/Akt and Nrf2 pathways, then suppression of pro-apoptotic caspase-3, and suppression of NF-B that reduce the expression of proinflammatory cytokines such as IL-1, and TNF- [50, 86]

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Allow to air dry for 10 seconds

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Interestingly, when we allowed also the degradation rate of Srxn1-GFP and the Nrf2-dependent production rate of SRXN1 mRNA to be refitted, there was a significant improvement (for more information, see Supplement Section 1 \)C and humidified 5% CO\(_2\) atmosphere environment