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Int J Biomed Res

doi:10.1007/s00280-020-04218-6

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Most studies on the paracellular route of transport describe at least two populations of pores regulated by TJs: (1) a high capacity charge selective pore permeable to small ions and small uncharged molecules (referred to as the pore pathway), and (2) a much larger low-capacity pore (commonly referred to as the leak pathway) permeable to large ions and molecules irrespective of charge