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Inhibition of dextran sulfate sodium (DSS)-induced colitis by curcumin in mice has been associated with a downregulation of the expression of p38-MAPK and pro-inflammatory cytokine TNF- and a reduction of myeloperoxidase (MPO) activity, a marker of neutrophil infiltration in intestinal mucosa (29)

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Consequently, direct extrapolation to the majority of sporadic human PD cases should be made cautiously [149]

Moreover, the finding that endogenous IGF-1 regulation by miR-483-3p is critical for human NK cell cytotoxic activity provides new mechanistic insights into the biology of human NK cells