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The apoptosis signal-regulating kinase 1 (ASK1) is involved in APAP-induced activation of JNK, with ASK1- deficient mice being protected against the sustained JNK elevation [55] and a specific ASK1 inhibitor decreasing JNK activation at 1.5 h and preventing JNK translocation to mitochondria [56]

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This is the most frequently reported effect and typically resolves within minutes to hours

With diverse experience in various medical fields, including general practice and internal medicine, he also holds diplomas in emergency medicine and anaesthetics