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The normal vascular endothelium regulates vasodilation and vasocontraction, proliferation and antiproliferation of vascular smooth muscle cells, coagulation and anticoagulation, inflammation and anti-inflammation, and oxidation and antioxidant effects, which work in balance to regulate and maintain vascular tone and structure [53]

In Table 3, among individuals who have ever smoked (A), all three mediators show statistically significant indirect effects, although their magnitudes vary

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Withdrawal from smokeless tobacco is as difficult as smoking and may cause intense cravings, depressed mood, and irritability

doi: 10.2139/ssrn.5064634 98