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Early haematological response begins with reticulocytosis (increased production of immature red blood cells) typically by day 3-4 of treatment , particularly with injectable forms, though the full resolution of symptoms may take several weeks to months

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Building on this work, Viennese pharmacologist Oleh Hornykiewicz demonstrated selective striatal dopamine depletion in PD brains, prompting the first clinical administration of intravenous LD in 1961, which produced dramatic motor improvements

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