M., Brewer, W
Recently, we found that NRF2 regulates the serine biosynthesis pathway through ATF4 and PHGDH, which led to an independence from exogenous serine sources [43]
Apoptosis in cumulus cells, but not in oocytes, May influence bovine embryonic developmental competence
In addition to these mechanisms, there are other non-enzymatic antioxidants within cells that can directly interact with free radicals and scavenge them, thereby mitigating harmful lipid peroxidation and preventing ferroptosis
Among them one by GSH, an abundant tripeptidyl molecule, contributes to the body and lung health status ( Resistance to viral diseases positively correlates with the extent of GSH stores ( Interestingly, preventive supplementation of NAC significantly reduced the incidence of clinically apparent influenza, especially in higher risk elderly population ( The deficiency of GSH in the alveolar fluid in ARDS patients was found to correlate with the increased ROS-mediated lung cell injury and inflammation (Soltan-Sharifi et al., 2007): Soltan-Sharifi also reported that supplemental NAC resulted in the prevention of this aggravating condition (Soltan-Sharifi et al., 2007)
