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Patients with gout frequently have comorbid conditions that predispose to renal dysfunction and increased urate reabsorption, including hypertension and metabolic syndrome (insulin resistance) (see: Who Gets Gout?) Impaired urinary alkalinization in metabolic syndrome likely contributes to elevated risks of uric acid urolithiasis in the gout patient population

establishing a baseline hs-CRP level provides a reference point for understanding the inflammatory state someone is starting from

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