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The thresholds reported in preclinical literature vary: PCB-157 : 10 g/kg to 1 mg/kg subcutaneously or intraperitoneally depending on the model

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The standard cagrilintide monotherapy titration follows this schedule: 0.25 mg weekly for weeks 1-4, then 0.5 mg for weeks 5-8, then 1.0 mg for weeks 9-12, then 1.7 mg for weeks 13-16, and finally 2.4 mg for week 17 onward as the maintenance dose