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Gong, M

Patients with various degrees of TBI may suffer from a long period of secondary injury, which plays a key role in determining the final severity and recovery of nerve injury after TBI ( FIGURE 1 Inflammation Neuroinflammation is a key pathophysiological mechanism of secondary injury, as it can produce neurotoxic effects on neurons through oxidative stress, apoptosis, and excitotoxicity (Sulhan et al., 2020)