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Confirmed deficiency on blood testing is the key reason for treatment

As for the best treatment duration, in an open-label trial GlyNAC supplementation for 16-weeks or 24-weeks resulted in similar outcomes, while withdrawing GlyNAC for 12-weeks led to loss/decrease of benefits

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Slow COMT : The COMT gene plays an important role in breaking down estrogen and other substances in the body

Indeed, other than cystine, amino acids such as glutamine, methionine, serine, leucine, and glucose were at two to five-fold higher concentrations than those in the plasma of healthy human subjects