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Simultaneous administration of all three constituents (ALL) resulted in oxidative DNA damage in both the nucleus and mitochondria, accumulation of DSBs, reduced mitochondrial membrane potential, induction of minority mitochondrial outer membrane permeabilization, accumulation of cytosolic free DNA, and increased expression of inflammatory cytokines such as IL-6 and IL-1

Among the risks associated with heavy marijuana use are cognitive impairment, mental health decline, and disrupted brain development, particularly in younger users

THC: The Psychoactive Component Mind-Altering Effects : THC is the compound responsible for the mind-altering high that is often associated with cannabis use