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Furthermore, the authors validated the capacity of MnO 2 -coated mesoporous silica nanoparticles (MSNs) to control drug release, and the camptothecin (CPT)-loaded MnO 2 -MSNs showed sustained CPT release after the addition of GSH (Figure 1G)

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8.2 Metabolism and elimination of curcumin Curcumins bioavailability in humans is mostly limited by poor intestinal absorption, rapid hepatic metabolism, and rapid systemic elimination, even at high doses of 12 g/day (104)