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Key residues 38 YGSL 41 , D 68 , R 72 , E 115 and Y 143 are responsible for high affinity substrate binding via salt bridge interaction with the glutamate (E 115 ), hydrogen bonding as well as a cation -interaction involving Y 143

doi: 10.3389/fonc.2021.745584

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These substances are believed to aid in the removal of fat from the liver and help prevent or treat fatty liver disease

Evidence suggests that RGD enhances cell attachment and spreading of osteoblasts onto scaffolds and graft material [140, 141, 159, 188] whilst increasing cellular proliferation and the expression of ALP, Runx2, osteocalcin, osteopontin and bone sialoprotein [141, 142, 146, 190, 191]