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Several medical reports, regulatory advisories, and reviews have documented severe, potentially life-threatening reactions tied to injectable glutathione especially when done in unregulated settings or with contaminated/inappropriately compounded products

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Thus, advanced experimental models, including 3D co-culture systems, organ-on-a-chip platforms, and humanized mouse models, should be prioritized to enhance the physiological relevance and translational potential of studies evaluating natural metabolite interventions