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Mice exhibiting fasting blood glucose levels above 16.7 mmol L 1 were considered as successfully established and were subsequently randomly assigned into six groups (n = 6): PBS (Blank control group), G, M-CuP solution, D-CuP solution, G/M-CuP and G/D-CuP

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For instance, when peripheral tissues become inflamed, the related signals might be transmitted to the brain through these receptors on the neurons, and the brain could then respond to these signals via neural pathways, thus regulating the level of peripheral inflammation

It addresses a bottleneck