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The growth-promoting and angiogenic properties of the compound make its use in pregnancy particularly concerning: aberrant angiogenesis during placental development is associated with preeclampsia and fetal growth disorders

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The tumors tortuous and hyperpermeable vessels [13,14,15,16] and the near absence of functional lymphatic vessels [17, 18] raise the interstitial fluid pressure (IFP) within breast tumors (Table 2)

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