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This impairment of DNA synthesis affects the rapidly dividing cells of the bone marrow earlier than other cells, resulting in the production of large, immature, hemoglobin-poor red blood cells (macrocytosis), as well as effects on white blood cells, including abnormal (hypersegmented) neutrophils and reduced overall cell counts (pancytopenia)

The most common risk factors are the following: Bruising or swelling may occur if the needle hits a blood vessel or damages soft tissue

The results of a study carried out in 2013 indicated that trend

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