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combined, the GH AUC rose to roughly 4,259.2 308.0 g/Lh higher than the arithmetic sum of the two single-agent responses, which the authors characterized as apparent synergy

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Acknowledgements We thank all researchers and colleagues from Key Laboratory of Molecular Biology in Beijing Anding Hospital of Capital Medical University and Beijing Institute for Brain Disorders for their great support Ethics declarations Competing interests The authors declare that they have no conflict of interest

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This is consistent with enhancing pro-survival signaling, relieving negative regulation of the PI3K/AKT pathway, upregulating BCL-2 and CCND1, and leading to marked reductions in apoptosis in vitro [27, 28]

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