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On the contrary, amino acid transporter is one of the most downregulated DEGs induced by MT treatment (Table 1)

However, when the level of long-chain acylcarnitines (LCACs) is abnormally elevated, not only is it a signal of mitochondrial dysfunction but its high concentration can also aggravate mitochondrial damage and further deteriorate mitochondrial function [20, 21]

In this study, histopathological examination of both right sides in two groups was of great value not only in confirming the type of melasma but also adding another objective tool in evaluation of treatment response in two groups, it demonstrated a decrease in melanin in basal cell layer in epidermal types and in melanin and melanophages in dermis in mixed types in H and E and MF stained sections after treatment compared with baseline

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Her course of treatment required ICU admission and intubation to protect her airway due to CNS depression which is a known complication of high doses of such medication