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Lysosomotropic agents like chloroquine and hydroxychloroquine impair lysosomal function and robustly inhibit trained immunity (169)

The efficacy of -3 PUFA was tested in a study involving 40 patients aged between 814 years, who were given 10 g daily of margarine enriched with either 650 mg of eicosapentaenoic acid (EPA)/docosahexaenoic acid (DHA), for 16 weeks, and the result was positive [148]

Cohort 1 received 600 mg NAC twice daily for 3 months and then 600 mg three times daily for 3 months, cohort 2 received 1200 mg twice daily for 3 months and then 1200 mg three times daily for 3 months, and cohort 3 received 1800 mg twice daily for 3 months and then 1800 mg three times daily for 3 months

Common side effects include increased appetite, water retention, and potential tingling or numbness in the extremities

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