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359 The diminished efficacy of HSCs can be attributed not only to telomere shortening but also to an increased risk of DNA damage 360 and elevated levels of ROS production

exposed HepG2 cells to 520 M TSN for up to 24 h and showed a 15% loss of cell viability that correlated with partial GSH depletion, a three-fold increase in LPO, and reduced GPx4 expression