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The dihexa half life only matters if the compound reaching circulation is structurally intact

Notably, NS workers demonstrated stronger SARS-CoV-2-specific T-cell responses, and sleep metrics were not significantly associated with vaccine immunogenicity, suggesting that primary immune responses may be resilient to short-term sleep loss in healthy individuals 121

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Neurochem Res 47:35253542 Zhang X, Zhang Q, Tu J, Zhu Y, Yang F, Liu B, Brann D, Wang R (2015) Prosurvival NMDA 2 A receptor signaling mediates postconditioning neuroprotection in the hippocampus

This network potentially maintains the disease course and shapes inflammation in the CNS, which is essential for initiating and dominating the progressive phase of MS