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Importantly, RWD can help reveal opportunities for earlier diagnosis by identifying common pathways and warning signs that precede diagnosis

[DOI] [PubMed] [Google Scholar] 138.Cordero M.D., Alcocer-Gmez E., de Miguel M., Culic O., Carrin A.M., Alvarez-Suarez J.M., Bulln P., Battino M., Fernndez-Rodrguez A., Snchez-Alcazar J.A

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In contrast, for the D3 dopamine receptor, PKC phosphorylation of the receptor leads to GRK- and arrestin-independent desensitization and internalization, in a process requiring the interaction of the D3 receptor with the actin-binding protein filamin A (Cho et al ., 2007)