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doi: 10.1016/j.freeradbiomed.2018.03.043 187 JiaJJGengWSWangZQChenLZengXS
Potential amylin-class concerns Excessive appetite suppression Delayed gastric emptying Dehydration Hypoglycemia when combined with insulin Changes in oral medication absorption Long-term uncertainty In addition, long-term cardiovascular, pancreatic, gallbladder, psychiatric, immunogenicity, and weight-regain risks remain uncertain
Downstream marker assays can include phosphoprotein panels, transcript level response mapping, and functional proxy assays that explore changes in cellular state under controlled exposure logic