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Different studies have shown that cigarette smoke causes a reduction in cell viability and induction of apoptosis in respiratory hair cells20, opposite mitogenic effects or pro-apoptotic depending on the cigarette smoke concentration21 or even an impairment on epithelial regeneration upon injury.22 Animal studies have shown that chronic and intermittent exposure to cigarette smoke cause morphological alterations to the epithelium of the entire respiratory tract, from hyperplasia in lower concentrations, all the way to loss of cilia and metaplasia with keratinization in higher concentrations, and also submucosal thickening and inflammation with neutrofilic and mononuclear inflammatory cells infiltrate.23 Also, Hamm et al.24 showed that the cigarette-induced respiratory mucosa inflammatory reaction persists even after seven months of recovery

Dr Tim Chico, a reader in Cardiovascular Medicine and a consultant cardiologist at the University of Sheffield, had pointed out that of course the devices are not completely risk free, but they are proven to be significantly safer than their combustible counterparts, and must be therefore viewed and regulated in this context

Whatever its original purpose, it remains a unique addition to Van Goghs artistic output