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For example, the PARP inhibitor olaparib disrupts the SDF-1/CXCR4 axis to impair MDSC recruitment, leading to superior tumor reduction when combined with EGFRvIII-targeted CAR-T cells (178)
Guillemin R, Brazeau P, Bohlen P, Esch F, Ling N, Wehrenberg WB
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In addition, the inhibition of aspartate aminotransaminase GOT1 promotes labile iron release in PDAC through NCOA4-dependent ferritinophagy, highlighting GOT1 as a therapeutic target through the promotion of PDAC ferroptosis [24]