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In addition to GSTP1-1 inhibition, TLK199 has been shown to effectively inhibit multidrug resistance-associated protein 1 MRP1 (encoded by ABCC1 gene), which plays an essential role in multidrug resistance by its ability to effectively export an array of chemotherapeutic and other drugs out of the cell [100]

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This increase in oxidative stress, combined with low glutathione levels, can make you more prone to absentmindedness and the inability to focus and stay on task

However, the journey to lasting results extends far beyond the treatment room

Altogether, the investigation indicates an alternative option in CML therapy