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Poly ADP-ribose polymerase-1: an international molecule of mystery

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156 Besides, with the consumption of extracellular glutamine, GDH can also catalyze ammonia derived from glutaminolysis and -KG to support the synthesis of glutamate and downstream metabolites by reductive amination in a NADPH consumption manner to meet the cancer cells growth

Similar content being viewed by others Introduction Many conventional cancer therapies often lead to undesired side effects because they target proteins and cellular processes necessary for normal cell survival and proliferation, including various progenitor cell types