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Dorczok MC, Mittmann G, Mossaheb N, et al

468 Reconciling in vivo selectivity for Fe II with in vitro promiscuity remains a challenge

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Apart from the iron serving as co-factors and the iron stored in ferritin, the remaining divalent iron in the cytoplasm (a concentration of approximately 0.55 m) is called the free iron pool ( 2+ from generating ROS by the Fenton reaction to damage cells ( The uptake and storage of cellular iron mainly depend on the regulatory effects of the cytoplasmic protein iron regulatory protein (IRP)1 and IRP2 (Sty et al., 2011)

However, these effects can be subtle and may take time to manifest