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Interestingly, intranasal administration of epithalon peptide promoted c-Fos gene activation and subsequent increases in c-Fos only in the stress-induced rats, suggesting that epithalon contributes to pineal self-regulation under conditions of stress [17, 18]

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Nevertheless, its use is linked to elevated blood levels of creatinine and uric acid, as well as the eventual development of renal failure, which restricts its application

& Shadel, G