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As is true for many of the vitamins discovered in the early 20th century, the effects of B12 seemed miraculous, Heber explains

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Tolerability (e.g., gastrointestinal complaints and flushing) of the DMF drug was rated equal or better in most patients, showing that patients can switch form the traditional FAE mixture to the same dose of DMF with similar clinical relief but without any washout period

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Nausea, mild constipation, and occasional fatigue are common