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Vitamin B12 Health Professional Fact Sheet.

It is a cell-permeable, selective NNMT inhibitor that does not require cofactors for activity

Statistical analysis A sample size of 300 participants provided an effective power of at least 96% for the two co-primary endpoints, and at least 43% for all confirmatory secondary endpoints, which were tested in a predefined hierarchical order (Supplementary Table 4)

Additionally, Parasutterella relative abundance, which was increased in both the vehicle- and NNMTi-treated LD-switched groups relative to the controls, significantly correlated with several adipose tissue metabolites abundances