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Taken together, DNA methylome profiling of ESC-derived neurogenesis in vitro showed that the majority of de novo promoter methylation changes occur between the transition from pluripotent cells (ESCs) to lineage-restricted progenitor state (NPCs) and, most surprisingly, not during their further transition into terminally differentiated neurons (Meissner et al., 2008

The mechanisms already discussed, including enhanced angiogenesis, increased fibroblast activity, collagen synthesis upregulation, and improved cell migration, all contribute to faster resolution of tissue damage

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