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Several factors move the needle: Chinese Lunar New Year (January/February): Demand spikes for gifting, often causing retail prices in China to jump by 10-15%

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However, whether CSE activates an MKK3/p38-dependent PRKN Ser131 phosphorylation axis to causally suppress PRKN-mediated mitophagy, thereby driving mtROS accumulation and epithelial senescence, has not been established in COPD-relevant models

Confirmatory testing and documentation may be available depending on employer policy