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Whilst these observations suggest that TRF1 may be a suitable therapeutic target, they also raise questions regarding the function of TRF1 in telomere length maintenance and protection

Kruman II, Culmsee C, Chan SL, et al

Animal studies support the concept that elevated testicular temperature by 11.5 C resulted in reduction of the testes size, lower sperm production, abnormal forms [134] and lower motility [135,136,137]

The percentage of patients with erectile dysfunction secondary to radical retropubic prostatectomy for cancer is approximately 100% in the absence of bilateral nerve sparing, and approximately 50% after bnsrrp