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Preliminary animal work suggests methylcobalamin upregulates brain-derived neurotrophic factor (BDNF), a key mediator of central compensation

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For example, in macrophages, the activation of NF-B in response to LPS stimulation leads to the production of proinflammatory cytokines e.g., TNF- and interleukin-6 (IL-6), which are important for the initiation and regulation of the immune response [130]

Because GSH is mainly synthesized in astrocytes in the brain 25,26,27 and dopamine receptors on astrocytes are functional, we hypothesized that astrocytic dopamine receptors regulate GSH synthesis