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Aldosterone causes the kidney to reabsorb sodium and water, which also increases blood volume and pressure (Epstein 2001

Under conditions of stress, Kelch-like ECH-Associated Protein 1 (KEAP1), which is a cytosolic inhibitor of Nrf2, is oxidized, leading to stabilization and translocation of Nrf2 into the nucleus, where the transcription factor activates expression of genes crucial to antioxidant defense [68]

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Always use a broad-spectrum SPF 30+ daily, and discontinue use temporarily if experiencing significant redness, peeling, or discomfort.